Histamine H3 Receptor-Mediated Inhibition of Excitatory Synaptic Transmission in the Rat Dentate Gyrus In Vivo

The Japanese Journal of Pharmacology

Kazuho Abe¹  Hiroshi Saito¹  Ming Chang¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

关键词: Histamine H3 receptor;    Excitatory synaptic transmission;    Dentate gyrus;   

DOI  :  10.1254/jjp.77.251

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)We investigated the effects of histamine H3-receptor ligands on hippocampal synaptic transmission by using anesthetized rats in vivo. The medial perforant path was stimulated, and the population excitatory postsynaptic potential (pEPSP) and population spike were recorded from the granule cell layer of the dentate gyrus. Intracerebroventricular injection of the H3-receptor agonist (R)-α-methylhistamine decreased both the pEPSP and population spike, while H3-receptor antagonists, clobenpropit and thioperamide, increased both the pEPSP and population spike. These results suggest that the histaminergic system plays a role in inhibition of hippocampal synaptic excitation via the H3 receptor.

【 授权许可】

Unknown