Effects of Sodium Nitroprusside on the Catecholamine Synthetic Pathway in the Adrenal Medulla of Rats

The Japanese Journal of Pharmacology

Masako Asoh¹  Toshio Kumai¹  Masami Tanaka¹  Tomonori Tateishi¹  Shinichi Kobayashi¹ 

[1] Department of Pharmacology, St. Marianna University School of Medicine

关键词: Nitric oxide;    Sodium nitroprusside;    Tyrosine hydroxylase;    Catecholamine;    Adrenal medulla;   

DOI  :  10.1254/jjp.77.205

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(21)Cited-By(1)We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP+nicotine (Nic)-treated group were increased significantly compared to those in the control, Nic-treated and SNP-treated groups. Furthermore, methylene blue inhibited this increase in TH activity. The data suggest that the NO derived from SNP may increase TH through the guanylyl cyclase pathway in the presence of Nic.

【 授权许可】

Unknown