The Japanese Journal of Pharmacology | |
Effect of Lecithinized-Superoxide Dismutase on the Interstitial Pneumonia Model Induced by Bleomycin in Mice | |
Tomoko Sekiguchi1  Katsuyuki Horie1  Yusuke Hori1  Jiro Hoshino1  Syoji Mizuno1  Satoshi Miyauchi1  Chihiro Yamazaki1  | |
[1] Tokyo Research Institute, Seikagaku Corporation | |
关键词: Lecithinized-superoxide dismutase; nterstitial pneumonia; Bleomycin; | |
DOI : 10.1254/jjp.75.97 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(15)Cited-By(15)Superoxide anion (02-) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu, Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912080714208ZK.pdf | 330KB | download |