Effect of Lecithinized-Superoxide Dismutase on the Interstitial Pneumonia Model Induced by Bleomycin in Mice

The Japanese Journal of Pharmacology

Tomoko Sekiguchi¹  Katsuyuki Horie¹  Yusuke Hori¹  Jiro Hoshino¹  Syoji Mizuno¹  Satoshi Miyauchi¹  Chihiro Yamazaki¹ 

[1] Tokyo Research Institute, Seikagaku Corporation

关键词: Lecithinized-superoxide dismutase;    nterstitial pneumonia;    Bleomycin;   

DOI  :  10.1254/jjp.75.97

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(15)Superoxide anion (02-) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu, Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.

【 授权许可】

Unknown