Effect of Lecithinized-Superoxide Dismutase on the Rat Colitis Model Induced by Dextran Sulfate Sodium

The Japanese Journal of Pharmacology

Tomoko Sekiguchi¹  Katsuyuki Horie¹  Yusuke Hori¹  Jiro Hoshino¹  Syoji Mizuno¹  Satoshi Miyauchi¹  Chihiro Yamazaki¹ 

[1] Tokyo Research Institute, Seikagaku Corporation

关键词: Lecithinized-superoxide dismutase;    Dextran sulfate sodium;    Ulcerative colitis;   

DOI  :  10.1254/jjp.74.99

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(8)Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu, Zn-SOD, has a longer half-life in blood and higher cell affinity than unmodified SOD. The effects of PC-SOD were evaluated using the rat ulcerative colitis model induced by 3% dextran sulfate sodium. Intravenous injection of rats with 0.5 or 1 mg/kg of PC-SOD suppressed the progression of bloody stools, the formation of erosion, and the infiltration of the colon with inflammatory cells. Furthermore, it also reduced the increase of leukocytes in blood. Thus, PC-SOD may have therapeutic potential in the treatment of ulcerative colitis.

【 授权许可】

Unknown