期刊论文详细信息
The Japanese Journal of Pharmacology
Beneficial Effects of Dilazep on the Palmitoyl-L-carnitine-Induced Derangements in Isolated, Perfused Rat Heart: Comparison with Tetrodotoxin
Hiroko Hashizume1  Johji Arakawa1  Yasushi Abiko1  Akiyoshi Hara1 
[1] Department of Pharmacology, Asahikawa Medical College
关键词: Dilazep;    Tetrodotoxin;    Long-chain acylcarnitine;    Na+ channel;    heart (rat);   
DOI  :  10.1254/jjp.74.147
学科分类:药理学
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society
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【 摘 要 】

References(28)Cited-By(4)The present study was carried out to determine the effect of dilazep, having an inhibitory effect on the Na+ channel, on the mechanical dysfunction and metabolic derangements induced by palmitoyl-L-carnitine in isolated rat heart and to compare the effect of dilazep with that of tetrodotoxin, a specific inhibitor of the Na+ channel. Rat hearts were perfused aerobically at a constant flow according to Langendorff s technique and paced electrically. Palmitoyl-L-carnitine (5 μM)decreased the left ventricular developed pressure and increased the left ventricular end diastolic pressure (i.e., it produced mechanical dysfunction), decreased the tissue level of adenosine triphosphate and increased the tissue level of adenosine monophosphate (i.e., it produced metabolic derangements). These mechanical and metabolic alterations induced by palmitoyl-L-carnitine were attenuated by either dilazep (1 μM)or tetrodotoxin (3 μM). On the other hand, neither dilazep nor tetrodotoxin modified the mechanical function and energy metabolism of the normal (palmitoyl-L-carnitine-untreated)heart. These results suggest that inhibition of the Na+ channel with dilazep or tetrodotoxin is responsible, at least in part, for attenuating the palmitoyl-L-carnitineinduced mechanical dysfunction and metabolic derangements in the heart.

【 授权许可】

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