Molecular Pharmacology of Voltage-Dependent Calcium Channels

The Japanese Journal of Pharmacology

Sheryl Koch¹  Tsutomu Kobayashi¹  Gyula Varadi¹  Minoru Wakamori¹  Yasuo Mori¹  Gabor Mikala¹  Arnold Schwartz¹ 

[1] Institute of Molecular Pharmacology and Biophysics, University of Cincinnati College of Medicine

关键词: Ca2+ channel;    Ca2+ antagonist;    Peptide toxin;    Inorganic blocker;   

DOI  :  10.1254/jjp.72.83

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(262)Cited-By(44)Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca2+-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological responses. Recently, introduction of molecular biology to pharmacology has brought a great deal of information about the molecular basis of drug action in Ca2+ channels. In this review, we attempt to overview recent progress in understanding the interactions between Ca2+ channels and their blockers, namely Ca2+ antagonists, from a molecular and structural point of view.

【 授权许可】

Unknown