Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats

The Japanese Journal of Pharmacology

Osamu Katsumata³  Maki Saito¹  Masataka Majima¹  Kazuyuki Kizuki²  Makoto Katori¹  Shohei Yamashina³  Keiichi Adachi¹  Michiko Ogino¹  Takashi Ohno¹ 

[1] Department of Pharmacology, Kitasato University School of Medicine;Department of Biochemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo;Department of Anatomy, Kitasato University School of Medicine

关键词: Renal kallikrein;    Spontaneously hypertensive rat;    Oxytocin;    Diuresis;    Natriuresis;   

DOI  :  10.1254/jjp.71.11

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(37)Cited-By(4)Urinary kallikrein excretion during oxytocin (OT) infusion were studied in anesthetized (sodium pentobarbital, 50 mg/kg, i.p.) young (4-weeks-old) spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). OT-infusion (30 nmol/kg/30 min) to WKY significantly increased urinary excretion of the active kallikrein from the basal levels (25.4±5.6 10-2 × AU/15 min, n=5) to 37.3±5.0 10-2 × AU/ 15 min (P<0.05, n=5) and 50.7±17.1 10-2× AU/15 min (P<0.05, n=5) 15 and 30 min after the start of OT-infusion, respectively. In SHR, OT-infusion did not increase the urinary excretion of active kallikrein, but did decrease the urine volume and sodium excretion. The concentration of the active kallikrein in the kidney of WKY was not changed by OT-infusion, but that of SHR was slightly increased. The OTinfusion resulted in significantly higher concentrations of the active kallikrein in SHR kidney than in WKY kidney. These results suggest that less excretion of urinary kallikrein in SHR during OT-infusion may be attributable to a lower response in the secretion of kallikrein from the kidney.

【 授权许可】

Unknown