Involvement of the Renal Kallikrein-Kinin System in Furosemide-Induced Natriuresis in Rats

The Japanese Journal of Pharmacology

Naoya Inamura¹  Masataka Majima¹  Michiko Ogino¹  Tomoe Fujita¹  Tomonori Iwata¹  Yuji Kumagai¹  Yasuhiro Ikeda¹ 

[1] Department of Pharmacology,Kitasato University School of Medicine,1-15-1 Kitasato,Sagamihara-shi,Kanagawa 228-8555,Japan

关键词: B2-receptor antagonist;    FR173657;    Furosemide;    Natriuresis;    Renal kallikrein;   

DOI  :  10.1254/jjp.84.133

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(27)Cited-By(7)This study examined whether the renal kallikrein−kinin system(KKS)is involved with furosemide−induced natriuresis in rats.Intravenous administration of furosemide(10 mg/kg)to anesthetized rats infused with physiological saline(saline)increased renal KK excretion as well as urine volume and urinary excretions of sodium, chloride and potassium.The change in the increase of renal KK excretion by furosemide at a dose of 1.0mg/kg relative to the control was larger than that of urine volume.Pretreatment with a B2−receptor antagonist, 8−[3−[N−[(E)−3−(6−acetamidopyridin−3−yl)acryloylglycyl]−N−methylamino]−2, 6−dichloro−benzyloxy]−2−methylquinoline(FR173657, 100mg/kg), significantly inhibited the furosemide−induced natriuresis by 58.6%.The effect of FR173657 on the furosemide−induced natriuresis was also examined in hypotonic saline−loading rats.Similar to the saline−loading rats, urinary excretion of sodium collected during the first 8 h in metabolic cages significantly reduced by 22.4% when FR173657(100mg/kg)was given concurrently with furosemide(100mg/kg)and hypotonic saline(5% of body wt.).These results indicate that furosemide increased renal KK excretion through a mechanism different from a washout mechanism and induced natriuresis partly through an augmentation of the renal KKS following the increase in renal KK excretion in both the saline− and hypotonic saline−loading rats.

【 授权许可】

Unknown