Effect of Leukotriene D4 on Tracheal Mucociliary Transport Velocity in Quails

The Japanese Journal of Pharmacology

Hirofumi Kai¹  Kazuo Takahama¹  Shusheng Tai¹  Yoichiro Isohama¹  Takeshi Miyata¹ 

[1] Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

关键词: Tracheal mucociliary transport;    Leukotriene D4;    ONO-1078;   

DOI  :  10.1254/jjp.70.195

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(4)We investigated the effect of leukotriene D4 (LTD4) on tracheal mucociliary transport in quails. Topical application of LTD4 (0.2-2 ng) to tracheal mucosa dose-dependently increased mucociliary transport velocity (MCTV) in 5 or 10 min after application. Forty minutes after application of 2 ng of LTD4, MCTV was decreased to about 841o of that in the control group. Both the transient increase and the subsequent decrease induced by 2 ng of LTD4 were blocked by ONO-1078 (Pranlukast: 4-oxo-8-[4-(4phenylbutoxy)-benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran) (0.03-3 mg/kg, i.m.), a specific leukotriene antagonist. These results suggest that LTD4 possesses a biphasic effect on tracheal mucociliary transport through leukotriene receptors.

【 授权许可】

Unknown