Fenamates Potentiate the α1-Adrenoceptor-Activated Nonselective Cation Channels in Rabbit Portal Vein Smooth Muscle

The Japanese Journal of Pharmacology

Yoshiki Waniishi¹  Kazunori Yamada¹  Ryuji Inoue¹  Yushi Ito¹ 

[1] Department of Pharmacology, Faculty of Medicine, Kyushu University

关键词: Cation channel opener;    Smooth muscle;    Fenamate;   

DOI  :  10.1254/jjp.70.81

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(6)The agonistic action of fenamates on the α1-adrenoceptor-activated cationic current (Icat) in rabbit portal vein smooth muscle was investigated with the whole-cell patch clamp technique. At −50 mV, the fenamates (100-500 μM) increased Icat dose-dependently, up to several fold. This increase was not accompanied by changes in the reversal potential and strongly inhibited by 500 μM Cd2+ or 10 mM procaine. The enhancing effect of fenamates was also observed on the cationic current activated by intracellularly applied GTPγS. These results suggest that fenamates may be useful as a new class of activator for receptor-operated cation channels in smooth muscle.

【 授权许可】

Unknown