Anti-inflammatory Effect of Flurbiprofen Tape Applied Percutaneously to Rats with Adjuvant-Induced Arthritis

The Japanese Journal of Pharmacology

Toshihiro Akashi¹  Yutaka Ikeda¹  Shinji Uchida¹  Takashi Morishita¹ 

[1] Research Laboratory, Yutoku Pharmaceutical Industries Co., Ltd.

关键词: Anti-inflammatory;    Tape;    Flurbiprofen;    Transdermal penetration;   

DOI  :  10.1254/jjp.69.37

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(11)The anti-inflammatory effect of flurbiprofen tape (FP-T) by topical application was investigated, and the findings were compared with the results of oral administration of flurbiprofen to adjuvant arthritic rats. The topical application of FP-T significantly suppressed both applied and non-applied hind paw edema, with a potency similar to that seen with the oral administration of flurbiprofen. Body weight also increased with these treatments. Plasma levels of flurbiprofen differed little between topical application of FP-T and oral administration of flurbiprofen. Gastric damage induced by topical application of FP-T was significantly less than that seen in case of oral administration of flurbiprofen. These results suggest that the anti-inflammatory effects of FP-T cannot be entirely explained by flurbiprofen permeating inflamed tissue below the application site; rather, flurbiprofen penetrating into the systemic circulation may explain these actions.

【 授权许可】

Unknown