Bulletin of the Korean chemical society | |
Efficient Transdermal Penetration and Improved Stability of L-Ascorbic Acid Encapsulated in an Inorganic Nanocapsule | |
Yang-Su Han1  Kyoung-Chan Park1  Sun-Young Lee1  Jae-Hun Yang1  Jin-Ho Choy1  | |
关键词: Layered inorganic material; L-Ascorbic acid; Encapsulation; Intercalation; Transdermal penetration; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
Encapsulation of L-ascorbic acid (vitamin C) within a bio-compatible layered inorganic material was achieved by coprecipitation reaction, in which the layered inorganic lattice and its intercalate of vitamin C are simultaneously formed. The nano-meter sized powders of vitamin C intercalate thus prepared was again encapsulated with silica nano-sol to form a nanoporous shell structure. This ternary nanohybrid of vitamin Clayered inorganic core-SiO2 shell exhibited an enhanced storage stability and a sustained releasing of vitamin C. Furthermore, the nano-encapsulation of vitamin C with inorganic mineral was very helpful in delivering vitamin C molecules into skin through stratum corneum, facilitating transdermal penetration of vitamin C in topical application.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010238899ZK.pdf | 333KB | download |