Barium and Strontium Can Substitute for Calcium in Stimulating Nitric Oxide Production in the Endothelium of Canine Coronary Arteries

The Japanese Journal of Pharmacology

Taku Nagao¹  Yoshinori Harada¹  Fumihiro Ohara¹  Jun Yamazaki¹ 

[1] Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

关键词: Barium;    Strontium;    Nitric oxide;    Endothelium;    Coronary artery;   

DOI  :  10.1254/jjp.68.25

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(27)Cited-By(3)We investigated whether Ba2+ and Sr2+ can substitute for Ca2+ in stimulating the nitric oxide (NO) production and cause relaxation in vascular smooth muscle. Ba2+ and Sr2+, like Ca2+, relaxed K+ -depolarized canine coronary arteries in the presence of diltiazem. The Ba2+- and Sr2+-induced relaxation was endothelium-dependent and was largely inhibited by NG-monomethyl-L-arginine (L-NMMA) and NG-nitro-L-arginine (L-NNA), but not by indomethacin. These cations increased cyclic GMP levels in the coronary artery to a similar extent, and the increment was completely abolished by L-NMMA. The relaxation induced by each cation was attenuated in the presence of a combination of propranolol, phentolamine and atropine, and L-NNA markedly inhibited any remaining relaxation. This indicates that these cations produce endothelium-dependent relaxation through NO production as well as the relaxation mediated by neurotrasmitters. The present study suggests that Ba2+ and Sr2+ can substitute for Ca2+ in the activation of the NO synthase pathway in the endothelium of canine coronary arteries.

【 授权许可】

Unknown