Vasodilative Effect of Adrenomedullin in Isolated Arteries of the Dog

The Japanese Journal of Pharmacology

Kumi Nakamura¹  Kenjiro Mori¹  Hiroshi Toda¹  Kenji Kangawa³  Masahiro Kakuyama¹  Kiyoshi Terasako¹  Yoshio Hatano² 

[1] Department of Anesthesia, Kyoto University Hospital;Department of Anesthesiology , Wakayama Medical College;Department of Biochemistry, National Cardiovascular Center Research Institute

关键词: Adrenomedullin;    Calcitonin gene-related peptide;    Vasodilatation;   

DOI  :  10.1254/jjp.67.259

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(21)Adrenomedullin is known to induce profound hypotension in vivo, but the direct effect of this peptide on isolated arteries has not been demonstrated. This study estimated the vasodilative effects of adrenomedullin in comparison with those of calcitonin gene-related peptide (CGRP) in basilar, mesenteric, coronary, renal and femoral arteries isolated from the dog. Adrenomedullin (3 to 100 nM) and CGRP (1 to 30 nM) induced concentration-dependent relaxation of these arteries with and without endothelium, and the relaxing effects were slightly greater in endothelium-intact arteries than in denuded ones. The vasodilative potency of adrenomedullin relative to CGRP was smaller in the femoral artery than in basilar, mesenteric, coronary and renal arteries.

【 授权许可】

Unknown