Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Primary Culture of Rat Type II Pneumocytes

The Japanese Journal of Pharmacology

Hirofumi Kai²  Michio Tsuruoka¹  Manabu Okumura¹  Kazuo Takahama²  Yoichiro Isohama²  Takeshi Miyata² 

[1] Department of Pharmacy, Miyazaki Medical College;Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

关键词: Xanthine;    Type II pneumocyte;    Phosphatidylcholine secretion;   

DOI  :  10.1254/jjp.67.165

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(5)Xanthine derivatives, pentoxifylline, aminophylline, theophylline and chinoin-170, increased phosphatidylcholine secretion in a primary culture of rat type II pneumocytes. However, these xanthines alone had no effect on intracellular cAMP levels in type II pneumocytes. In contrast, terbutaline-induced secretion of phosphatidylcholine was augmented by these xanthines, and the augmentation depended on the increase of cAMP levels. These results suggest that the xanthines induce phosphatidylcholine secretion possibly through cAMP-dependent and cAMP-independent pathways in the primary culture of rat type II pneumocytes.

【 授权许可】

Unknown