The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019

Critical Care

Qiongfang Zha¹  Xin Zhou²  Kebin Cheng³  Ruilin Liu⁴  Runzhi Huang⁵  Tong Meng⁶  Junhua Zheng⁷  Dingyu Zhang⁸ 

[1] Department of Respiratory and Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, 200127, Shanghai, China;Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, 100 Haining Road, 200080, Shanghai, China;Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 200433, Shanghai, China;Department of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China;Department of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China;Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of Education, 200065, Shanghai, China;Shanghai General Hospital, 100 Haining Road, 200080, Shanghai, China;Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, 200072, Shanghai, China;Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, 200072, Shanghai, China;Wuhan Jinyintan Hospital, 430023, Wuhan, China;

关键词: Coronavirus disease 2019;    Carcinoembryonic antigen;    Carcinoembryonic antigen-related cell adhesion molecules;    Developing neutrophils;    Type II pneumocyte;   

DOI  :  10.1186/s13054-021-03661-y

来源: Springer

【 摘 要 】

BackgroundThe coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known.ObjectiveThe aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism.MethodsThe retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively.ResultsIn total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell–cell communication.ConclusionThis study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell–cell communication of developing neutrophils and type II pneumocyte.

【 授权许可】

CC BY