Inhibitory Action of Benidipine on Balloon Catheterization-Induced Intimal Thickening of the Carotid Artery in Rats

The Japanese Journal of Pharmacology

Hiroyuki Satoh¹  Shin-ichi Ide¹  Akira Karasawa¹  Mari Kondoh¹ 

[1] Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

关键词: Benidipine;    Intimal thickening;   

DOI  :  10.1254/jjp.65.89

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)We examined the effect of benidipine, a long lasting Ca2- channel blocker, on balloon catheterization-induced intimal thickening of the carotid artery in rats. In the carotid arteries of vehicle-treated rats, neo-intima formation and elevation of DNA content was observed at 14 days after the surgery. Benidipine (5 mg/kg, p.o., b.i.d.) halved the intimal thickening and suppressed the elevated DNA-content in the balloon catheter-injured artery. These results suggest that benidipine may be useful for the treatment of vascular proliferative diseases like restenosis following percutaneous transluminal angioplasty.

【 授权许可】

Unknown