Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

The Japanese Journal of Pharmacology

Takao Kaneyuki²  Tadaomi Morimasa²  Kiyofumi Yamada¹  Takaaki Hasegawa¹  Tsutomu Kameyama³  Toshikiyo Shohmori²  Seiichi Ishihara³  Tetsuo Hayashi¹  Toshitaka Nabeshima¹ 

[1] Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine;Department of Neurology, Okayama University Medical School;Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University

关键词: Kamikihito;    [3H]QNB binding;    [3H]TCP binding;   

DOI  :  10.1254/jjp.64.303

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(2)Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(1-[2-thienyl]cyclohexyl)-3, 4-piperidine (TCP) in the rat brain. The Bmax but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.

【 授权许可】

Unknown