期刊论文详细信息
The Japanese Journal of Pharmacology | |
Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding | |
Takao Kaneyuki2  Tadaomi Morimasa2  Kiyofumi Yamada1  Takaaki Hasegawa1  Tsutomu Kameyama3  Toshikiyo Shohmori2  Seiichi Ishihara3  Tetsuo Hayashi1  Toshitaka Nabeshima1  | |
[1]Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine | |
[2]Department of Neurology, Okayama University Medical School | |
[3]Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University | |
关键词: Kamikihito; [3H]QNB binding; [3H]TCP binding; | |
DOI : 10.1254/jjp.64.303 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
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【 摘 要 】
References(15)Cited-By(2)Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(1-[2-thienyl]cyclohexyl)-3, 4-piperidine (TCP) in the rat brain. The Bmax but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.【 授权许可】
Unknown
【 预 览 】
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