Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats

The Japanese Journal of Pharmacology

Tsuneo Iwasaki¹  Yoshihiro Hiraga²  Yugo Ikeda²  Naoyoshi Miura²  Naoki Nakata²  Yoshiaki Tanaka²  Hisayuki Ohata¹ 

[1] Institute of Psychology, University of Tsukuba;Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

关键词: Serotonin reuptake inhibitor;    Learning and memory;    Scopolamine;   

DOI  :  10.1254/jjp.62.203

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(5)A novel serotonin reuptake inhibitor, (-)trans 4-(4-fluorophenyl)-3-(4-methoxyphenoxy-methyl)piperidine hydrochloride (FG-7080), was investigated for its effects on scopolamine-induced impairments in memory tasks of rats. In the radial-arm maze task, FG-7080 (3 mg/kg, p.o.) improved the impaired performance. FG-7080 (1 mg/kg, p.o.) administered before the acquisition trial reduced the acquisition deficits in the passive avoidance task. Thus, the compound showed improving effects in the appetitive and aversive memory tasks. These findings suggest that FG-7080 may ameliorate the cognitive impairments caused by the cholinergic dysfunction.

【 授权许可】

Unknown