Inhibitory Effects of Magnoshinin and Magnosalin, Compounds from "Shin-i" (Flos Magnoliae), on the Competence and Progression Phases in Proliferation of Subcultured Rat Aortic Endothelial Cells

The Japanese Journal of Pharmacology

Shinjiro Kobayashi¹  Ikuko Kimura¹  Takeshi Nagaura¹  Masayasu Kimura¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

关键词: Neolignan-derivatives (magnoshinin and magnosalin);    Endothelial cell proliferation;   

DOI  :  10.1254/jjp.60.59

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(9)Cited-By(5)Anti-proliferative effects of magnoshinin and magnosalin derived from “Shin-i” (Flos magnoliae) were investigated using subcultured endothelial cells (EC) of rat aorta. The inhibitory effects of magnoshinin were 2-fold greater at 10 μg/ml than that of magnosalin on the increase in cell number when EC were stimulated by 5% fetal bovine serum. In the 3H-thymidine incorporation monitored at 3 hr-intervals, magnoshinin (0.1-3 μg/ml) prolonged the starting time of DNA synthesis and reduced the rate of incorporation into EC. Magnosalin (0.3-3 μg/ml) reduced only the incorporation rate. These results suggest that magnoshinin inhibits both the competence phase and progression phase, but magnosalin preferentially inhibits the progression phase in EC proliferation.

【 授权许可】

Unknown