The Japanese Journal of Pharmacology | |
The Acyl-CoA Synthetase Inhibitor Triacsin C Enhanced Eicosanoid Release in Leukocytes | |
Satoshi Omura1  Hiroshi Tomoda1  Mitsuhiro Abe2  Kohji Yamaki2  Sachiko Oh-ishi2  | |
[1] Kttasato Institute;Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University | |
关键词: Triacsin C; Acyl-CoA synthetase; Arachidonic acid; | |
DOI : 10.1254/jjp.59.417 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(6)Cited-By(17)Triacsin C was previously reported to inhibit long-chain acyl-CoA synthetase and to reduce the production of acyl-CoA in rat neutrophils dose and time-dependently. We found that preincubation with triacsin C inhibited the incorporation of labeled arachidonic acid into rat neutrophils. Furthermore, when triacsin C-treated neutrophils were stimulated with the Ca-ionophore A23187, they released an increased amount of eicosanoids into the culture medium. These results indicate that triacsin C suppressed acylation of arachidonic acid, which resulted in an increase in its metabolites.
【 授权许可】
Unknown
【 预 览 】
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