The Acyl-CoA Synthetase Inhibitor Triacsin C Enhanced Eicosanoid Release in Leukocytes

The Japanese Journal of Pharmacology

Satoshi Omura¹  Hiroshi Tomoda¹  Mitsuhiro Abe²  Kohji Yamaki²  Sachiko Oh-ishi² 

[1] Kttasato Institute;Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University

关键词: Triacsin C;    Acyl-CoA synthetase;    Arachidonic acid;   

DOI  :  10.1254/jjp.59.417

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(6)Cited-By(17)Triacsin C was previously reported to inhibit long-chain acyl-CoA synthetase and to reduce the production of acyl-CoA in rat neutrophils dose and time-dependently. We found that preincubation with triacsin C inhibited the incorporation of labeled arachidonic acid into rat neutrophils. Furthermore, when triacsin C-treated neutrophils were stimulated with the Ca-ionophore A23187, they released an increased amount of eicosanoids into the culture medium. These results indicate that triacsin C suppressed acylation of arachidonic acid, which resulted in an increase in its metabolites.

【 授权许可】

Unknown