Beneficial Effect of Intravenous Taurine Infusion on Electroretinographic Disorder in Taurine Deficient Rats

The Japanese Journal of Pharmacology

Hiromasa Araki¹  Shuichi Tanaka¹  Sumio Kuroda¹  Mitsuo Sano¹  Michinori Hasegawa¹  Chiaki Shimada¹  Kiyotsugu Isaka¹ 

[1] Research and Development Center, Fuso Pharmaceutical Industries, Ltd.

关键词: Taurine;    Electroretinogram;    Guanidinoethyl sulfonate;    Retina;    Taurine deficient rat;   

DOI  :  10.1254/jjp.59.43

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(37)Cited-By(3)We investigated the effect of intravenous taurine infusion on the electroretinogram (ERG) of taurine-deficient rats produced by treatment with guanidinoethyl sulfonate (GES), a taurine transport inhibitor. Mother rats were fed a taurine-free diet and given drinking water containing 1% GES from 2 weeks of gestation to weaning. The same feeding conditions were applied to male offspring after weaning. Both ERG measurement and continuous infusion of taurine at a dose of 10, 30 or 100 mg/animal/day were performed for 3 weeks from 7 to 10 weeks of age. GES-treatment reduced a- and b-wave amplitudes to 50% of the control levels and also increased b-wave latencies. Intravenous infusion of taurine improved these ERG abnormalities in a dose-dependent manner. Taurine concentrations in plasma, eyes and brain were also decreased by treatment with GES, and dose-dependent recovery was observed after infusion with taurine, although the concentrations of other amino acids were not affected by GES-treatment and infusion of taurine. Observations of morphological changes revealed that the retinal damage in GES-treated animals was decreased by taurine infusion. These results indicate that the changes in ERG and retinal structure observed in taurine deficiency are improved by intravenous infusion of taurine.

【 授权许可】

Unknown