The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor

Cell Structure and Function

Hiroshi Yoshida¹ 

[1] Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University

关键词: Apaf-1;    apoptosis;    mitochondria;    caspase;    cytochrome c;   

DOI  :  10.1247/csf.28.3

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(67)Cited-By(4)Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of C. elegans, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.

【 授权许可】

Unknown