The Pebble GTP Exchange Factor and the Control of Cytokinesis

Cell Structure and Function

Robert Saint¹  Alyssa Harley¹  Louise O'Keefe¹  W. Gregory Somers¹ 

[1] Centre for the Molecular Genetics of Development and Dept. of Molecular Biosciences, Adelaide University

关键词: cytokinesis;    G proteins;    Rho;    Drosophila;    actin cytoskeleton;   

DOI  :  10.1247/csf.26.619

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(52)Cited-By(16)Several G proteins of the Rho family have been shown to be required for cytokinesis. The activity of these proteins is regulated by GTP exchange factors (GEFs), which stimulate GDP/GTP exchange, and by GTPase activating proteins (GAPs), which suppress activity by stimulating the intrinsic GTPase activity. The role of Rho family members during cytokinesis is likely to be determined by their spatial and temporal interactions with these factors. Here we focus on the role of the pebble (pbl) gene of Drosophila melanogaster, a RhoGEF that is required for cytokinesis. We summarise the evidence that the primary target of PBL is Rho1 and describe genetic approaches to elucidating the function of PBL and identifying other components of the PBL-activated Rho signalling pathway.

【 授权许可】

Unknown