Drosophila Male Meiosis as a Model System for the Study of Cytokinesis in Animal Cells

Cell Structure and Function

Elisabetta Bucciarelli¹  Maurizio Gatti¹  Silvia Bonaccorsi¹  Maria Grazia Giansanti¹ 

[1] Istituto Pasteur-Fondazione Cenci Bolognetti

关键词: cytokinesis;    central spindle;    contractile ring;    meiosis;    Drosophila;   

DOI  :  10.1247/csf.26.609

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(64)Cited-By(18)Drosophila male meiosis offers unique opportunities for mutational dissection of cytokinesis. This system allows easy and unambiguos identification of mutants defective in cytokinesis through the examination of spermatid morphology. Moreover, cytokinesis defects and protein immunostaining can be analyzed with exquisite cytological resolution because of the large size of meiotic spindles. In the past few years several mutations have been isolated that disrupt meiotic cytokinesis in Drosophila males. These mutations specify genes required for the assembly, proper constriction or disassembly of the contractile ring. Molecular characterization of these genes has identified essential components of the cytokinetic machinery, highlighting the role of the central spindle during cytokinesis. This structure appears to be both necessary and sufficient for signaling cytokinesis. In addition, many data indicate that the central spindle microtubules cooperatively interact with elements of the actomyosin contractile ring, so that impairment of either of these structures prevents the formation of the other.

【 授权许可】

Unknown