Phosphoinositide Signalling Enzymes in Human T Lymphocytes : Modulation of Phosphoinositidase C Isoform Gamma 1 upon Interferon Treatment

Cell Structure and Function

Angela di Baldassarre¹  Amelia Cataldi¹  Antonio Caracino²  Iole Robuffo³  Rosa Alba Rana¹  Sebastiano Miscia¹ 

[1] Istituto di Morfologia Umana Normale, Università di Chieti;Divisione di Chirurgia Generate, Ospedale "Spirito Santo";Istituto di Citomorfologia Normale e Patologica del CNR

关键词: calcium binding protein;    endoplasmic reticulum;    lectin binding site;    heat shock protein;   

DOI  :  10.1247/csf.20.143

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(26)Cited-By(1)In human T lymphocytes immunohlotting analysis of phosphoinositidase C (PIC) isoforms has shown that gamma 1 is the most represented isoform both at the cytoplasmic and nuclear level, and that interferon beta produces, within 90min of treatment, an increase of its expression. These results, also supported by immunoelectronmicroscopic investigation, strongly suggest the involvement of PIC gamma1 in the cascade of molecular events generated by the interaction between interferon and its cell surface receptors.

【 授权许可】

Unknown