Proliferator-Activated Receptor (PPAR): Structure, Mechanisms of Activation and Diverse Functions

Cell Structure and Function

Kiyoto Motojima¹ 

[1] Department of Biochemistry, School of Pharmaceutical Sciences, Toho University

关键词: peroxisome;    peroxisome proliferator;    PPAR;    orphan receptor;    hepatocarcinogenesis;   

DOI  :  10.1247/csf.18.267

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(101)Cited-By(22)The structurally diverse xenobiotic peroxisome proliferators (PPs) increase the number of peroxisomes per cell and the levels of several enzymes, and cause hepatomegaly, often leading to hepatocarcinogenesis in a species- and tissue-specific manner. The deadlocked problems of the molecular mechanism of PP action and its physiological meanings have begun to be understood through cDNA cloning of a PP-activated receptor (PPAR). PPAR, a member of the steroid/thyroid/vitamin superfamily of nuclear receptors, has isoforms and differentially heterodimerizes with other nuclear receptors, providing potential mechanisms not only for species-and tissue-specific actions but also for diverse actions of PPs. Recent findings related to PPAR are summarized, and its possible role in lipid metabolism and involvement in PP-induced hepatocarcinogenesis are discussed.

【 授权许可】

Unknown