Difference in Laminin Expression Between High and LowMetastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Cell Structure and Function

Koh Nanimi¹  Toshihiko Sakai¹  Mamoru Isemura²  Tatsuya Abe¹  Minoru Okayama³  Toshiaki Kikuchi¹  Kayoko Oguri³  Ken Satoh¹  Satoshi Sindoh¹  Masakichi Motomiya¹ 

[1] Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University;School of Food and Nutritional Sciences, University of Shizuoka;Clinical Research Institute, National Nagoya Hospital

关键词: Laminin;    Laminin Receptor;    Lewis Lung Carcinoma;    Metastasis;   

DOI  :  10.1247/csf.18.183

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(18)Cited-By(1)We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings showthe possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

【 授权许可】

Unknown