Quantitative Evaluation of Glycine Crystal Growth from Solution by a Phase Field Simulation

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Yoshiyuki Shirakawa¹  Jusuke Hidaka¹  Atsuko Shimosaka¹  Kazunori Kadota²  Yohei Kamano¹ 

[1] Department of Chemical Engineering and Materials Science, Doshisha University;Osaka University of Pharmaceutical Sciences

关键词: Morphology;    Ostwald Rule;    Polymorphism;    Supersaturation Ratio;    Amino Acids;   

DOI  :  10.1252/jcej.15we030

来源: Maruzen Company Ltd

【 摘 要 】

References(55)Quantitative evaluation of crystal growth is important to understand the mechanism upon crystallization from supersaturated solution. In the present work, the prediction of crystal growth was quantitatively performed by phase-field simulation. The program on the crystal growth following the concentration difference as the driving force was developed. The validity of simulation results was evaluated by comparing the crystal morphology obtained by phase-field simulation with experimental results. The rate of crystal growth was estimated by calculating the change in crystal morphology against time. The crystal growth rate was different between constant and non-constant supersaturation ratios. The growth rate on each face strongly depended on the supersaturation ratio. This simulation method would help to design operating conditions for obtaining the desired crystal morphology. We could quantitatively predict the crystal growth by introducing the substance-specific parameters.

【 授权许可】

Unknown