Drug Concentration–Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Hideki Kawamata¹  Kakuji Tojo¹  Daisuke Mori¹ 

[1] Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology

关键词: Transdermal Drug Delivery;    Dissolution-Type TTS;    Mathematical Model;    Simulation;    Plasma Concentration;   

DOI  :  10.1252/jcej.36.45

来源: Maruzen Company Ltd

【 摘 要 】

References(10)Cited-By(2)In medical treatment, a constant plasma concentration for an extended period of time is preferable for some diseases, while pulsatile delivery or delayed delivery is also required to avoid the tolerance and set a delayed time for medication. The dissolution-type TTS is expected to achieve pulsatile delivery. In this work, a mathematical model was proposed for the prediction of the plasma concentration–time profile following the application of the dissolution-type TTS. In vivo animal data was compared with the simulated profile together with the model parameters determined independently. The calculated concentration–time profile well agreed with the in vivo animal data.

【 授权许可】

Unknown