Enhancement of Enantioselectivity by Altering Alcohol Concentration for Esterification in Supercritical CO2

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Jau-Yann Wu¹  Ming-Tsai Liang¹ 

[1] Department of Chemical Engineering, I-Shou University

关键词: Enantioselectivity Enhancement;    Enzymatic Resolution;    Substrate;    Cosolvent;    Supercritical Carbon Dioxide;   

DOI  :  10.1252/jcej.32.338

来源: Maruzen Company Ltd

【 摘 要 】

References(14)Cited-By(6)This work used Candida rugosa lipase to resolve racemic Naproxen by esterification with ethanol, n-butanol, n-hexanol or n-decanol in supercritical CO2. It was found that the lipase enantioselectively esterified (S)-Naproxen within all systems. The enantiomeric ratio increased four folds by slightly decreasing the alcohol concentration. The effect of the alcohol concentration on the enantioselectivity was greater than that of changing acyl acceptors.

【 授权许可】

Unknown