Multi-layered Gelatin/Acacia Microcapsules by Complex Coacervation Method

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Yasuo Hatate¹  Yoshimitsu Uemura¹  Yoshinobu Kawano²  Hidekazu Yoshizawa¹  Kazuya Ijichi¹ 

[1] Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University;Department of Materials Science, Faculty of Engineering, Miyazaki University

关键词: Microcapsule;    Complex Coacervation;    Gelatin/Acacia Membrane;    Membrane Formation;    Sustained Release;   

DOI  :  10.1252/jcej.30.793

来源: Maruzen Company Ltd

【 摘 要 】

References(12)Cited-By(10)Microencapsulation of biphenyl was carried out by varying the colloid concentration to investigate the microencapsulation of large oil droplets by the complex coacervation method. In dilute colloid solutions, the traditional model of the complex coacervation method is supported where coacervate droplets formed in the bulk solution adhere to oil droplets. However, in a solution of 3.0 wt% colloid, it was clarified that the microcapsule membrane was formed not by adhesion of the full-grown coacervate droplets, but by growth of small coacervate droplets adhering to oil droplets.Spherical gelatine/acacia microcapsules with thicker membrane were successfully prepared by repeating the conventional complex coacervation method. The affinity of coacervate droplets to a core material is found to be a dominant factor in microencapsulation in the complex coacervation method.The multi-layered microcapsules endured the release of encapsulated biphenyl, however the single-layered microcapsules were ruptured within a short time in release experiments, and a serious initial burst was induced. The multi-layered microcapsules prepared by repeating the conventional complex coacervation can be applied as a dosage form in the controlled release of active agents.

【 授权许可】

Unknown