CONTROL OF CELL AND LACTATE CONCENTRATION IN A HOLLOW-FIBER BIOREACTOR FOR LACTIC ACID FERMENTATION

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

KAZUYUKI SHIMIZU¹  TAKESHI KOBAYASHI¹  MASAKAZU MATSUBARA¹  ZHONGPING SHI¹  SHINJI IIJIMA¹  TAKAHIRO TAKEBAYASHI¹  HIDETAKA HATANAKA¹  ENHAO WANG¹ 

[1] Department of Chemical Engineering, Nagoya University

关键词: Biochemical Engineering;    Hollow Fiber Bioreactor;    Lactic Acid Fermentation;    Control of Cell;    Lactate Concentrations;   

DOI  :  10.1252/jcej.21.36

来源: Maruzen Company Ltd

【 摘 要 】

References(8)Cited-By(13)From the amount of alkaline solution supplied for neutralizing the broth, lactate concentration was estimated on line in the fermentation of Streptococcus cremoris. Cell concentration in the broth was also monitored on line using a turbidimeter. The monitoring system was applied to the culture accompanied by filtration, and both cell and lactate concentrations were controlled at constant levels by on-off control. In this culture, cells and lactate were continuously produced at constant rates, and the concentrations in the fermenter were kept constant.

【 授权许可】

Unknown