Biochemical Activities of main Group Metal Chelates of Curcuminoid Analogues

International Journal of Biomedical and Advance Research

S. Sindhu¹  John V. D.¹  Seena Thomachan¹ 

关键词: Anti cancer;    Toxicity;   

DOI  :  10.7439/ijbar.v6i4.1928

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Turmeric and its active chemical constituents, curcuminoids, have been reported to possess a number of medicinal uses particularly in the treatment of inflammation, angiogenesis, tumorigenesis, diabetes etc. Structurally, curcuminoids are 1,7-diaryl-1,6-heptadiene-3,5-diones and are known to form metal complexes similar to other 1,3diketones. It has been reported that metal complexation of these ?, ?,-unsaturated 1,3-diketones lead to dramatic changes in their biochemical activities including antitumour, antimicrobial and antioxidant activity. The two new curcuminoid analogues namely 1,7-bis(2,5-dimethyl phenyl) hepta-1,6-diene-3,5-dione and 1,7-bis(2,4-dihydroxy phenyl)hepta-1,6-diene-3,5-dione have been synthesized and were complexed with main group metals Al(III), Ga(III) & In(III). They were characterized by IR, UV,1 H NMR,13 CNMR and Mass spectral techniques.In vitrocytotoxic? studies were done with ligand and metal complexes (Al,Ga & In)? against DLA and EAC cells using Tryptan blue exclusion method and? antibacterial study of the compounds were done using agar well diffusion method. Thein vivoantitumour activity of the ligand and complexes were determined by using DLA cells in mice? and? compared with standard anticancer drug cyclophosphamide

【 授权许可】

CC BY