Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

International Journal of Biomedical and Advance Research

Roshan Kumar Mahat¹  Sudeep Kumar¹  Imran Mustafa¹  Anita Sharma¹  Manisha Arora¹ 

关键词: PON-1;    Lipid profile;    Psoriasis;    Cholesterol;   

DOI  :  10.7439/ijbar.v6i2.1678

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background:Psoriasis is a common recurrent disease of skin characterised by excessive cell proliferation and incomplete differentiation in lesional epidermis. Aim:The present study was aimed to determine lipid parameters and paraoxonase activity in psoriatic patients.Methods:The study included 100 subjects of age group 30-60 years, out of which 50 were patients of psoriasis (Case group) and rest 50 were normal healthy individuals of same age group (Control group). Result:Our study showed significant increase (p<0.001) in the levels of Cholesterol, Triglyceride, LDL and VLDL in patients of psoriasis as compared to control group. Also, we found significant decreased levels of serum HDL and PON-1 in psoriatic patients as compared to control group. Conclusion:Our study concludes that altered lipid profile and paraoxonase may be responsible for the higher prevalence of systemic complication such as metabolic and cardiovascular diseases.

【 授权许可】

CC BY