Serum cholinesterase as diagnostic marker of liver disease

International Journal of Biomedical and Advance Research

Mitul Chhatriwala¹  Rita Shah¹  Nadeem Shaikh¹  Ruchi Shantilal Gokani¹  Bhavita Patel¹  Pranay Jadav¹ 

关键词: Serum cholinesterase;    Liver Function Test;    Sensitivity;   

DOI  :  10.7439/ijbar.v5i9.890

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background: Liver disease is leading cause of morbidity and mortality worldwide. Cholinesterase?is a family of enzymes thatcatalysethehydrolysisof the neurotransmitteracetylcholine?into?choline?and?acetic acid. It is an enzyme synthesized by hepatocytes and its serum levels reflect the synthetic function of liver. Objectives: To estimate serum cholinesterase in liver disease patients and to compare serum cholinesterase level with other liver function tests like SGOT, SGPT, ALP and Bilirubin levels. Methodology: The present cross sectional study was conducted at the Biochemistry department of tertiary care institute.Thirty patients with liver disease were included in the group A and 30 healthy patients not having liver disease were enrolled in group B as control .Serum cholinesterase and Liver Function Tests were estimated in all participants. Results: The level of cholinesterase were significantly lower in liver disease patients.Serum cholinesterase was 3424.77 ? 2149.30 in group A vs.7320.77 ? 1577.26 in group B (P<0.05). It is 90% sensitive and 100% specific. Conclusion: From the present study it is concluded that serum cholinesterase can serve as better diagnostic marker of liver disease.

【 授权许可】

CC BY