Antioxidant status and level of oxidants in patients of coronary heart disease

International Journal of Biomedical and Advance Research

Hundal Parchwani¹  Naved Ahmad¹  Sudha Jha¹ 

关键词: Oxidative stress;    Coronary heart disease;    Superoxide dismutase;    Malondialdehyde;    Lipid peroxidation;   

DOI  :  10.7439/ijbar.v4i11.529

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Objectives:- The aim of our study was to investigate the predictive value of an oxidative stress and free radical scavenger enzyme superoxide dismutase (SOD) in patients having coronary heart disease (CHD). Material & Methods:- The study population contained 200 subjects divided into two groups, 150 patients with CHD & 50, age & sex matched healthy control subjects. All biochemical parameters MDA, SOD & Lipid profile were analyzed by spectrophotometer and autoanalyser. ?P value <0.05 was taken as statistically significant. Results: -In our study we have found that lipid profile level (Mean ? SD) of CHD patients & controls i.e. total cholesterol (TC) level 241.24 ? 45.83 in CHD patients & in control subjects were 169.6 ? 22.24, triglycerides (TG) levels 191.15 ? 52.54 in CHD patients & in control subjects were 113.32 ? 22.82, low density lipoprotein cholesterol (LDL-C) 167.69 ? 39.5 in CHD patients & in control were 97.03 ? 21.51, very low density lipoprotein cholesterol (VLDL) levels 38.43 ? 10.51in CHD patients & 22.67 ? 4.56 in controls. We have also found that the level of MDA in CHD patients & in control (Mean ? SD) were 5.68 ? 1.20 & 3.73 ? 1.17 & the level of SOD in CHD patients & in control (Mean ? SD) were 2.50 ? 0.18 & 3.31 ? 0.49. Conclusion: -Our study indicates an imbalance between lipid peroxidation, status of antioxidants & free radical scavenger enzyme in CHD. Therefore these biomarkers may be useful in diagnosis of coronary heart disease.

【 授权许可】

CC BY