Dexmedetomidine Added to Ropivacaine Prolongs Axillary Brachial Plexus Block

International Journal of Biomedical and Advance Research

Neelofar Jan¹  Mohd Rafiq Najar¹  Feroz Ahmad Dar¹ 

关键词: Dexmedetomidine;    Ropivacaine;    Brachial Plexus Block;   

DOI  :  10.7439/ijbar.v4i10.501

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background and Objectives : We evaluated the effect of adding dexmedetomidine to ropivacaine for axillary brachial plexus blockade. The primary endpoints were the onset and duration of sensory and motor block and duration of analgesia. Methods : Eighty patients scheduled for elective forearm and hand surgery were divided into 2 equal groups in a randomized, double-blind fashion. The 4 main nerves in the axilla (musculocutaneus, radial, median, ulnar) were identi??d using neural stimulation. Patients were assigned randomly into 2 groups. In group R (n=40), 40ml (200 mg) of 0.5% ropivacaine +1ml saline and in group RD (n=40), 40ml (200 mg) of 0.5% ropivacaine +1ml dexmedetomidine (50?g) were given. Motor and sensory block onset times, block durations, and duration of analgesia were recorded. Results : Demographic data and surgical characteristics were similar in both groups. Sensory and motor block onset times were shorter in group RD than in group R (P<0.05). Sensory and motor blockade durations were longer in group RD than in group R (P<0.001). Duration of analgesia was longer in group RD than in group R (P<0.001). Systolic arterial blood pressure levels in group RD at 10, 15, 30, 45, 60, 90, and 120 minutes were signi??antly lower than those in group R (P<0.05). Diastolic arterial blood pressure levels in group RD at 60, 90, and 120 minutes were signi??antly lower than those in group R (P<0.05). Heart rate levels in group RD, except basal measurements, were signi??antly lower than those in group R (P<0.05). In group RD, bradycardia was observed in 7 patients, although there was no bradycardia in group R (P<0.05). Conclusions : Dexmedetomidine added to ropivacaine for axillary brachial plexus block shortens the onset time and prolongs the duration of the block and the duration of postoperative analgesia. However, dexmedetomidine also may lead to bradycardia.?

【 授权许可】

CC BY