International Journal of Biomedical and Advance Research | |
PRION PROTEIN AS A PATHOGEN: A REVIEW | |
Manish K Jalandhra1  Monish Sharma1  Prof. Sanjeev Thacker1  Bhupender Kumar Nimiwal1  | |
关键词: Prion protein; Transmissible spongiform encephalopathies; cellular form; scrapie form; Creutzfeldt-Jakob disease; fatal familial insomnia; Gerstmann Straussler Scheinker syndrome; kuru; | |
DOI : 10.7439/ijbar.v3i7.574 | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Scholar Science Journals | |
【 摘 要 】
Prion proteins (PrP) are associated with transmissible spongiform encephalopathies (TSE), which are invariably fatal diseases characterized by loss of motor control, dementia, and paralysis wasting. The ????rotein-only???hypothesis proposes that TSEs are caused by the conversion of a ubiquitous ????ellular form???of PrP (PrP C ) into an aggregated ????crapie form???(PrP Sc ). According to this model, the prion protein (PrP) would at the same time be target and infectious agent in TSEs, which could explain that this class of diseases can be traced to infectious, inherited, and spontaneous origins. PrP Sc
【 授权许可】
CC BY
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