EFFECT OF ANTIOXIDANTS (VITAMIN C) ON TISSUE CERULOPLASMIN FOLLOWING RENAL ISCHEMIA REPERFUSION IN WISTAR RATS

International Journal of Biomedical and Advance Research

Sheila Pai¹  Vinodini N A¹  Asha Kamath¹  Raghuveer CV¹  Anu Ranade¹  Yogesh Tripathi¹ 

关键词: toxicity;    renal ischemia;    reperfusion;    vitamin c;    ceruloplasmin;   

DOI  :  10.7439/ijbar.v3i1.269

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Aim : To study the effect of vitamin C on tissue ceruloplasmin level following renal reperfusionMaterials and Methods:Wistar albino rats were divided into Group I, II & III The Gr. II the experimental groups) were subjected to ischemia for 60 minutes followed by 24 hrs of reperfusion. The Gr.III were pre- treated with vitamin C ( 20mg/kg.bw ) for 30 days followed by 60 minute ischemia & 24hrs of reperfusion. After the experimental procedure was over; the kidneys were removed and homogenized. The homogenized tissue was used for biochemical estimation of lipid peroxidation & ceruloplasminResult: Asignificant in the levels of tissue lipid peroxidation (MDA) and increase in tissue ceruloplasmin level was observed in Group II compared to those in Group I (normal control). However, the pre- treated group (GroupIII) showed an increase in the levels of ceruloplasmin and a decrease in lipid peroxidation in comparison to group II. Conclusion:The results of the present study suggest that administration of vitamin C prior to renal ischemia reperfusion protect the renal tissue from the free radical induced reperfusion injury."

【 授权许可】

CC BY