International Journal of Biomedical and Advance Research | |
EFFECT OF ANTIOXIDANTS (VITAMIN C) ON TISSUE CERULOPLASMIN FOLLOWING RENAL ISCHEMIA REPERFUSION IN WISTAR RATS | |
Vinodini N A ; Yogesh Tripathi ; Raghuveer CV ; Anu Ranade ; Asha Kamath ; Sheila Pai | |
关键词: s toxicity; renal ischemia; reperfusion; vitamin c; ceruloplasmin; | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Scholar Science Journals | |
【 摘 要 】
Aim: To study the effect of vitamin C on tissue ceruloplasmin level following renal reperfusion Materials and Methods:Wistar albino rats were divided into Group I, II & IIIThe Gr. II the experimental groups) were subjected to ischemia for 60 minutes followed by 24 hrs of reperfusion. The Gr.IIIwerepre- treated with vitamin C (20mg/kg.bw) for 30 daysfollowed by 60 minute ischemia & 24hrs of reperfusion.After the experimental procedure was over; the kidneys were removed and homogenized. The homogenized tissue was used for biochemical estimation of lipid peroxidation & ceruloplasmin Result: A significant in the levels of tissue lipid peroxidation (MDA) and increase in tissue ceruloplasmin level was observed in Group II compared to those in Group I (normal control). However, the pre- treated group (GroupIII) showed an increase in the levels of ceruloplasmin and a decrease in lipid peroxidation in comparison to group II.Conclusion: The results of the present study suggest that administration of vitamin C prior to renal ischemia reperfusion protect the renal tissue from the free radical induced reperfusion injury.
【 授权许可】
CC BY
【 预 览 】
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