EFFECT OF ANTIOXIDANTS (VITAMIN C) ON TISSUE CERULOPLASMIN FOLLOWING RENAL ISCHEMIA REPERFUSION IN WISTAR RATS

International Journal of Biomedical and Advance Research

Vinodini N A ; Yogesh Tripathi ; Raghuveer CV ; Anu Ranade ; Asha Kamath ; Sheila Pai

关键词: s toxicity;    renal ischemia;    reperfusion;    vitamin c;    ceruloplasmin;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Aim: To study the effect of vitamin C on tissue ceruloplasmin level following renal reperfusion Materials and Methods:Wistar albino rats were divided into Group I, II & IIIThe Gr. II the experimental groups) were subjected to ischemia for 60 minutes followed by 24 hrs of reperfusion. The Gr.IIIwerepre- treated with vitamin C (20mg/kg.bw) for 30 daysfollowed by 60 minute ischemia & 24hrs of reperfusion.After the experimental procedure was over; the kidneys were removed and homogenized. The homogenized tissue was used for biochemical estimation of lipid peroxidation & ceruloplasmin Result: A significant in the levels of tissue lipid peroxidation (MDA) and increase in tissue ceruloplasmin level was observed in Group II compared to those in Group I (normal control). However, the pre- treated group (GroupIII) showed an increase in the levels of ceruloplasmin and a decrease in lipid peroxidation in comparison to group II.Conclusion: The results of the present study suggest that administration of vitamin C prior to renal ischemia reperfusion protect the renal tissue from the free radical induced reperfusion injury.

【 授权许可】

CC BY