Tramadol Safer and Effective Analgesic to Treat Chronic Pain: A Review

International Journal of Biomedical and Advance Research

Gulshan Pandey¹ 

关键词: Tramadol;    analgesic;    pain;    cyclooxygenase;   

DOI  :  10.7439/ijbar.v3i1.270

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

pain is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".Pain has now been equated to a ????ifth vital sign???highlighting the significance of pain management in patient care. Tramadol is a centrally acting analgesic, structurally related to codeine and morphine .It is effectively used to treat moderate-to-severe acute and chronic pain in diverse conditions. Tramadol is placed on the second step of WHO analgesic ladder and in contrast to traditional opioids, exerts its analgesic activity, a dual mechanism of action inhibiting transmission as well as perception of pain. Tramadol is more suitable than NSAIDs and coxibs for patient with GI, renal and cardiovascular problems. Combined with low dependence/abuse potential, it has proven to be of significant advantage over other agents, especially in the elderly.

【 授权许可】

CC BY