Revista Brasileira de Otorrinolaringologia | |
Clinical data and hearing of individuals with Alport syndrome | |
Santa Casa de Misericórdia, São Paulo1  Alves, Fatima Regina Abreu1  FCMSC-SP1  Ribeiro, Fernando de Andrade Quintanilha1  UNIFESP1  | |
关键词: hereditary; genetics; nephritis; hearing loss.; | |
DOI : 10.1590/S0034-72992008000600002 | |
学科分类:医学(综合) | |
来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial | |
【 摘 要 】
Alport Syndrome (AS) is a hereditary disease, characterized by nephropathy, often times with sensorineural hearing loss and ocular defects. AIM: to analyze the clinical and hearing information from individuals with AS, more specifically the correlation between renal disorder and hearing loss (HL). STUDY DESIGN: clinical prospective with cross-sectional cohort. MATERIALS AND METHODS: 37 individuals underwent otorhinolaryngological evaluation and were submitted to audiologic tests. For HL statistical analysis we considered only the results from the pure tone audiometries. RESULTS: of the 28 individuals with clinical alterations, we found 46.4% of DLX and 53.6% of AD. HL happened to 46.1% of the individuals evaluated. 12 patients presented HL in the audiometric test: 11.5% mild and 34.6% moderate. Comparing the normal relatives with those with renal disorder; all that had HL also had renal disorder. In 30.8% the curve shape was mild descending in the high frequencies and in 11.5% it was flat. CONCLUSIONS: The inheritance pattern distribution does not match literature descriptions. HL is a frequent extra-renal finding. There is an association between renal involvement and HL (p= 0.009). The most frequent curve shapes: mild descending in the high frequencies and flat. There was no association between HL and age. There is no correlation between the HL and gender in this group.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912050602938ZK.pdf | 671KB | download |