Influence of cyclic AMP on facial nerve regeneration in rats

Revista Brasileira de Otorrinolaringologia

Testa, José Ricardo Gurgel¹  Fukuda, Yotaka¹  Cruz, Oswaldo Laércio Mendonça¹  Toledo, Ronaldo Nunes¹  Ho, Paulo Lee¹  Borin, Andrei¹  UNIFESP¹  Instituto Butantan¹  Universidade Federal de São Paulo¹ 

关键词: cyclic amp;    histology;    facial nerve;    rat;    nerve regeneration.;   

DOI  :  10.1590/S0034-72992008000500007

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.RESULTS: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.CONCLUSION: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.

【 授权许可】

Unknown