Revista Brasileira de Otorrinolaringologia | |
Influence of cyclic AMP on facial nerve regeneration in rats | |
Testa, José Ricardo Gurgel1  Fukuda, Yotaka1  Cruz, Oswaldo Laércio Mendonça1  Toledo, Ronaldo Nunes1  Ho, Paulo Lee1  Borin, Andrei1  UNIFESP1  Instituto Butantan1  Universidade Federal de São Paulo1  | |
关键词: cyclic amp; histology; facial nerve; rat; nerve regeneration.; | |
DOI : 10.1590/S0034-72992008000500007 | |
学科分类:医学(综合) | |
来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial | |
【 摘 要 】
Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.RESULTS: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.CONCLUSION: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
【 授权许可】
Unknown
【 预 览 】
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