nm23 protein expression in metastatic and non-metastatic tongue squamous cell carcinoma

Revista Brasileira de Otorrinolaringologia

Universidade Estadual de Feira de Santana¹  Oliveira, Márcio Campos¹  USP¹  Hospital Dr. Luiz Antonio¹  Silveira, Éricka Janine Dantas da¹  Universidade Federal do Rio Grande do Norte, Natal¹  Costa, Antonio de Lisboa Lopes¹  Queiroz, Lélia Maria Guedes¹  Universidade do Estado Rio Grande do Norte¹  Morais, Maria de Lourdes Silva Arruda de¹ 

关键词: tongue squamous cell carcinoma;    immunohistochemistry;    nm23 protein.;   

DOI  :  10.1590/S0034-72992008000300008

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Oral squamous cells carcinoma (OSCC) shows unfavorable prognosis due to its invasion potential around the neighboring tissues and the elevated incidence of metastasis. AIM: the present paper aims at analyzing the immunohistochemical expression of the nm23 protein in metastatic and non-metastatic SCCs of tongue. METHODS: the immuno-expression to the nm23-hl protein was diagnosed in 35 tongue SCC (15 of which exhibiting metastasis). Nm23-hl immuno-scores were assigned as follow: score 0 = absent, 1 = focal and 2 = diffuse expression.RESULTS: The Fisher's exact test was performed and there was no statistical difference between the nm23-hl immuno-scores and the tongue SCCs studied cases (p=0.365), although 66.7% of metastatic cases presented negative nm23-hl expression.CONCLUSIONS: Protein nm23 was not associated with a positiveness for tongue SCC without metastasis. Thus, several others factors inherent to host and malignancy can be associated with the mechanisms that suppress the metastatic process in this disease.

【 授权许可】

Unknown