Moxifloxacine an adjunct in the treatment of periodontitis

Revista clínica de periodoncia, implantología y rehabilitación oral

Contreras Rengifo, Adolfo¹  Cruz Olivo, Edison Andrés¹  Ramirez Escobar, Jorge Hernán¹  Universidad del Valle, Cali, Colombia¹  Universidad Federal de Minas Gerais, Belo Horizonte, Brasil¹ 

关键词: Antibiotic;    Periodontitis;    Moxifloxacin;    Systemic inflammation;    Scaling and root planning;   

DOI  :  10.1016/j.piro.2014.06.001

来源: Sociedad de Periodoncia de Chile

【 摘 要 】

Periodontal disease results from infection by specific subgingival bacterial complexes organized in a biofilm. Biofilm protects bacteria and other microbial pathogens from host immune system defenses and from natural and artificial antibiotics. Patients with aggressive and chronic periodontitis from Central and South American countries have similar microbiological profiles. In both entities, the most frequent periodontopathogens associated with periodontal disease in Latin American patients are Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Tannerella forsythia, Eikenella corrodens and gram negative enteric rods. Supplemental antibiotics to the mechanical periodontal treatment are prescribed to reduce periodontopathic bacteria in the subgingival environment. Nonetheless, some bacterial species have developed antibiotic resistance due to their indiscriminate prescription in Latin America. Quinolones represent a new alternative in periodontal therapy, due to their activity against periodontopathogens and gram negative enteric rods, to reduced bacterial resistance, high tissue penetration, and good absorption. The aim of this review is to present an update on the use of antimicrobials as adjunctive therapy in the treatment of periodontitis, focusing on the potential therapeutic use of moxifloxacin.

【 授权许可】

Unknown