Presence of T Regulatory Cells in Chronic Periodontitis

Revista clínica de periodoncia, implantología y rehabilitación oral

Dutzan, N¹  Gamonal, J¹  Carré, L¹  García-Sesnich, J¹  Universidad de Chile, Chile¹  Henríquez, L¹  Aguillón, JC¹  Franco, ME¹ 

关键词: T regulatory cells;    periodontitis;    homing.;   

DOI  :  

来源: Sociedad de Periodoncia de Chile

【 摘 要 】

Periodontal disease requires a susceptible host to initiation, development and progression. T regulatory response is one of these inmunoregulatory characteristics of the susceptible host, which provide tolerance, tissular protection during infection without impairing the control of periodontopathogens. The aim of this study is to determinate the presence, homing and function of T regulatory cells (Tregs) in patients with chronic periodontitis. Ten biopsies were taken from pockets, the presence of Tregs markers (CD4, CD25, Foxp3), chemokines (CCL17, CCL22) and cytokines (TGF-p, IL-10) were determinate by immunohistochemistry. Cytokines also were detected with Western-Blot. Our results suggest a possible association between Tregs and periodontal infection, confirming homing and presence of Tregs. However, further studies are required to determine the possible imbalance with pro-inflammatory part Th17, that might explain the complex etiopathogenesis of periodontal disease.

【 授权许可】

Unknown