Mechanisms of immune-mediated skin diseases: an overview

Clinical and Experimental Rheumatology

F. Mascia¹  G. Tessari¹  G. Girolomoni¹  S. Beissert¹  P. Meroni¹  I. Cavazzana¹  S. Pastore¹ 

关键词: Skin;    atopic dermatitis;    keratinocytes;    T regulatory cells;    systemic sclerosis;    systemic lupus erythematosus;    anti-Ro/SSA antibodies;    anti-endothelial cell antibodies;    anti-fibroblast antibodies.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

ABSTRACT:The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.

【 授权许可】

Unknown