Safe handling of cytotoxics: guideline recommendations

Current Oncology

A.C. Easty⁴  R. Tozer¹  M. Cividino²  P. Savage³  R.E. White⁷  N. Coakley⁶  R. Cheng⁵ 

[1] Juravinski Hospital, Hamilton ONDepartment of Oncology, McMaster University, Hamilton, ON;Public Health Ontario, Hamilton ONSt. Joseph's Healthcare, Hamilton ON;Princess Margaret Cancer Centre, Toronto, On;Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ONCentre for Global eHealth Innovation, University Health Network/University of Toronto, Toronto, ON;Institute for Safe Medication Practices Canada (ISMP Canada);Cancer Care Ontario, Program in Evidence-Based Care, Hamilton ON Department of Oncology, McMaster University, Hamilton, ON;Centre for Global eHealth Innovation, University Health Network/University of Toronto, Toronto, ON

关键词: cytotoxic drugs;    guidelines;    hazardous waste;    cytotoxic drug administration;    personal protective equipment;    cytotoxic drug preparation;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Background This evidence-based practice guideline was developed to update and address new issues in the handling of cytotoxics, including the use of oral cytotoxics; the selection and use of personal protective equipment; and treatment in diverse settings, including the home setting. Methods The guideline was developed primarily from an adaptation and endorsement of an existing guideline and from three systematic reviews. Before publication, the guideline underwent a series of peer and external reviews to gather feedback. All comments were addressed, and the guideline was amended when required. The guideline applies to health care workers who could come into contact with cytotoxic drugs at any point in the medication circuit. The intended users are hospital administrators, educators, and managers; occupational health and safety services; and pharmacy and health care workers. Results The recommendations represent a reasonable and practical set of procedures that the intended users of this guideline should implement to minimize opportunities for accidental exposure. They are not limited to just the point of care; they cover the entire chain of cytotoxics handling from the time such agents enter the institution until they leave in the patient or as waste. Conclusions Reducing the likelihood of accidental exposure to cytotoxic agents within the medication circuit is the main objective of this evidenced-based guideline. The recommendations differ slightly from earlier guidelines because of the availability of new evidence.

【 授权许可】

Unknown