CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE)

Química Nova

Bersani-Amado, Ciomar Aparecida¹  Ames, Franciele Queiroz¹  Baldoqui, Debora Cristina¹  Formagio, Anelise Samara Nazari¹  Universidade Federal da Grande Dourados, Dourados, BR¹  Manholer, Daniele Domingos¹  Costa, Willian Ferreira da¹  Naressi, Maria Augusta¹  Universidade Estadual de Maringá, Maringá, BR¹  Pereira, Zefa Valdivina¹  Sarragiotto, Maria Helena¹ 

关键词:   Guettarda viburnoides;    chemical constituents;    anti-inflammatory activity;    antioxidant activity;   

DOI  :  10.5935/0100-4042.20150093

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Chemical investigation of Guettarda viburnoides (leaves) led to the isolation of ursolic acid, uncaric acid, secoxyloganin, and grandifloroside, along with a mixture of quercetin-3-O-β-D-galactopyranoside and quercetin-3-O-β-D-glucopyranoside, and of β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of their NMR data. The crude extract, ethyl acetate fraction, aqueous-methanol fraction, and grandifloroside showed significant DPPH free-radical scavenging activities with IC50 ranging from 18.92 to 26.47 µg mL-1. The topical administration of the crude extract and fractions markedly reduced the croton oil-induced mice ear edema in 67.0%-99.0%. Inhibition of tissue MPO activity was also observed, which demonstrated an anti-inflammatory effect of the G. viburnoides species.

【 授权许可】

Unknown